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KMID : 1039220150250010020
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Journal of Korean Society of Occupational and Environmental Hygiene
2015 Volume.25 No. 1 p.20 ~ p.26
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Evaluation of Biodurability of Korean Chrysotile withen The Lung of Rats
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Chung Yong-Hyun
Han Jeong-Hee
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Abstract
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Objectives: To evaluate the biodurability of Korean Chrysotile(KC), the changes in fibers numbers and changes in the element composition of fibers from the lung of Sprague-Dawley rats instilled KC(average size 4.74 ㎛, 59,043 × 106 fibers/mg) was estimated.
Methods: Rats were administered 1 mg KC(low group) or 2 mg KC(high group) by a single intratracheal instillation. At each time point(5 days, 5 weeks, 10 weeks), the numbers of KC fibers and the changes of element composition(atomic %) of KC fibers from the lung of the rats were analyzed with transmission electron microscope equipped with energy dispersive X-ray spectrometer.
Results: Over time, the number of fibers within the lungs of animals were reduced. The average length of the low and high group is significantly reduced from 5 days after administration. Over time, the fiber ratio of at least 5 ㎛ remaining in the lung tissue of the low concentration group was up but the high group was reduced. From day 5 after administration, the composition ratio(Mg) was significantly decreased in all groups.
Conclusions: Size and composition of Korean Chrysotile in the lung tissue of rats was changed from 5 days.
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KEYWORD
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biodulability, Korean Chrysotile, rat, transmission electron microscope equipped with energy dispersive X-ray spectrometer
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